Which condition affects the skin surface, particularly around the lips and eyes?

The condition that primarily affects the skin surface, particularly around the lips and eyes, is angioedema. Angioedema is characterized by localized swelling that can occur in various parts of the body, including the face, lips, and around the eyes. This swelling is often due to an allergic reaction, medication side effects, or other underlying issues. The rapid onset of swelling, especially in these sensitive areas, distinguishes angioedema, making it a condition of concern due to potential impacts on breathing or swallowing.

Blepharitis primarily involves inflammation or infection of the eyelids, not necessarily the skin around the eyes. Arrhythmia refers to irregular heartbeats and does not involve skin conditions. Neurodegeneration encompasses a range of disorders that affect the nervous system and does not pertain to skin issues. Therefore, angioedema is the condition that correctly aligns with the symptoms described, especially given its notable effects in facial areas.